TGX-221

Overview
Catalog #	bs-83415c-25mg
Product Name	TGX-221
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	TGX-221 is a potent (IC50 = 5 nM) and selective (1000-fold over p110α and p110γ) inhibitor of PI3-kinase isoform p110ß.1 Displays anti-thrombotic activity without affecting bleeding time.1,2 It significantly inhibited tumorigenesis in VHL, SETD2, PTEN, and CDKN2A mutated clear cell renal cell carcinoma.3 TGX-221 induced apoptosis in glioblastoma cells and inhibited cell migration and invasion.4
Description	CAS Number: 663619-89-4 Chemical Name: Potent and selective PI3Kß inhibitor Molecular Weight: 364.45 Formula: C21H24N4O2 Solubility: DMSO (10 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)