LY2090314

Overview
Catalog #	bs-83417c-25mg
Product Name	LY2090314
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	Wnt/ß-catenin pathway activator. LY2090314 is a highly potent (IC50 = 1.5 nM GSK-3α; 0.9 nM GSK-3ß) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ß-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4
Description	CAS Number: 603288-22-8 Chemical Name: Wnt/ß-Catenin pathway activator / GSK-3 inhibitor Molecular Weight: 512.54 Formula: C28H25FN6O3 Solubility: DMSO (>20 mg/ml) Physical Properties: Orange solid Purity: >98% by HPLC NMR (Conforms)