Osimertinib

Overview
Catalog #	bs-83423c-50mg
Product Name	Osimertinib
Specifications
Storage Buffer	Pale-yellow solid
Storage Condition	-20°C
Target
Product Information	Osimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4
Description	CAS Number: 1421373-65-0 Chemical Name: Mutant EGFR kinase inhibitor Molecular Weight: 499.62 Formula: C28H33N7O2 Solubility: DMSO (40 mg/ml) Physical Properties: Pale-yellow solid Purity: >98% by HPLC NMR (Conforms)