ICRF-193
| Overview | |
| Catalog # | bs-83425c-5mg |
| Product Name | ICRF-193 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5 |
| Description | CAS Number: 21416-88-6 Chemical Name: Topoisomerase II inhibitor Molecular Weight: 282.3 Formula: C12H18N4O4 Solubility: DMSO (4 mg/ml) Physical Properties: Off-white solid Purity: >98% by TLC NMR (Conforms) |
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