Ponatinib

Overview
Catalog #	bs-83426c-25mg
Product Name	Ponatinib
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1 Also inhibits PDGFR, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2 as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4
Description	CAS Number: 943319-70-8 Chemical Name: Bcr-Abl and multikinase inhibitor Molecular Weight: 532.56 Formula: C29H27F3N6O Solubility: DMSO (50 mg/ml) Ethanol (25 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC NMR (Conforms)