Tepotinib

Overview
Catalog #	bs-83435c-25mg
Product Name	Tepotinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Tepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
Description	CAS Number: 1100598-32-0 Chemical Name: c-Met inhibitor Molecular Weight: 492.58 Formula: C29H28N6O2 Solubility: DMSO (17 mg/ml with warming) Physical Properties: White solid Purity: >98% by TLC NMR (Conforms)