BPTES

Overview
Catalog #	bs-83439c-25mg
Product Name	BPTES
Specifications
Storage Buffer	White to off-white solid
Storage Condition	-20°C
Target
Product Information	Potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 µM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6
Description	CAS Number: 314045-39-1 Chemical Name: Glutaminase GLS1 inhibitor Molecular Weight: 524.68 Formula: C24H24N6O2S3 Solubility: DMSO (10 mg/ml) Physical Properties: White to off-white solid Purity: 98% by TLC, NMR (Conforms)