TPCA-1

Overview
Catalog #	bs-83442c-25mg
Product Name	TPCA-1
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	Selective inhibitor of IκB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation.1,2 Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1β-induced proliferation, migration, and invasion of HeLa cells.3,4 Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.5
Description	CAS Number: 507475-17-4 Chemical Name: Selective inhibitor of IκB kinase 2 (IKK2) Molecular Weight: 229.29 Formula: C12H10FN3O4S Solubility: DMSO (30 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by TLC NMR (Conforms)