SCR7 pyrazine

Overview
Catalog #	bs-83731c-5mg
Product Name	SCR7 pyrazine
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	SCR7 pyrazine enhances the efficiency of precise genome editing with CRISPR/Cas9 up to 19-fold via inhibition of nonhomologous end joining (NHEJ).1,2 May be employed in an optimized CRISPR/Cas9 method to target methylation in a site-specific manner enabling maintenance of gene silencing in vitro and in vivo.3 SCR7 pyrazine exhibits greater activity against DNA ligases I and III than DNA ligase IV.4 Induces cancer cell death via inhibition of NHEJ and potentiates the effect of double strand break-inducing therapeutic modalities.4,5
Description	CAS Number: 14892-97-8 Chemical Name: 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone Molecular Weight: 332.38 Formula: C18H12N4OS Solubility: DMSO (35 mg/ml) Physical Properties: Yellow solid Purity: >98% by TLC NMR (Conforms)