CU-CPT8m

Overview
Catalog #	bs-83724c-5mg
Product Name	CU-CPT8m
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	CU-CPT8m is a potent and selective antagonist of toll-like receptor 8 (TLR8) acting via stabilization of the TLR8 homodimer.1 It inhibits TNFα and IL-8 expression induced by the TLR8 agonist resiquimod at 1 mM and suppresses TLR8-mediated proinflammatory signaling in various cell lines, human primary cells and patient specimens. It reverses phenotypes involved in TLR8-activating fibroblasts.2 CU-CPT8m promotes erythroid cell proliferation and differentiation.3
Description	CAS Number: 125079-83-6 Chemical Name: 7-(3-Methylphenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxamide Molecular Weight: Formula: C14H12N4O Solubility: DMSO (20 mg/ml) Physical Properties: White solid Purity: >98% by HPLC, NMR (Conforms)