DMB

Overview
Catalog #	bs-83743c-5mg
Product Name	DMB
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	DMB is a small molecule glucagon-like peptide 1 (GLP-1) ago-allosteric modulator and agonist (EC50 = 101 nM).1 It significantly stimulated insulin secretion in BRIN-BD11 cells and decreased overall glucose excursion in mice.2 DMB is a direct and selective gasdermin D (GSDMD) agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD (EC50 = 700 nM).3 It induced pyroptosis in mouse cancer cell lines and induced tumor regression and enhanced antitumor immunity. DMB-treated tumor cells acted as a tumor vaccine in mice indicating that DMB can trigger immunogenic cell death that provides protective antitumor immunity.
Description	CAS Number: 281209-71-0 Chemical Name: N-tert-Butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine Molecular Weight: 348.2 Formula: C13H15Cl2N3O2S Solubility: DMSO (30 mg/ml with warming) Physical Properties: Yellow solid Purity: 98% by HPLC , NMR (Conforms)