VER-246608

Overview
Catalog #	bs-83761c-5mg
Product Name	VER-246608
Specifications
Storage Buffer	White to off-white solid
Storage Condition	-20°C
Target
Product Information	VER-246608 is a potent (IC50’s: PDK-1 = 35 nM, PDK-2 = 84 nM, PDK-3 = 40 nM, PDK-4 = 91 nM) and selective pan-pyruvate dehydrogenase kinase inhibitor.1 It decreased oxygen consumption and attenuated glycolytic activity (Warburg metabolism) under D-glucose/L-glutamine-depleted conditions. VER-246608 treatment of four cancer lines (PC-3, SW-1088, UM-22B, and MEF) under depleted D-glucose/L-glutamine conditions resulted in almost complete inhibition of cell growth. It also acted synergistically with doxorubicin in PC-3 and ES-2 cells.
Description	CAS Number: 1684386-71-7 Chemical Name: N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxybenzamide Molecular Weight: 552.96 Formula: C28H23ClF2N4O4 Solubility: DMSO (>25 mg/ml) Physical Properties: White to off-white solid Purity: >98% by HPLC NMR (Conforms)