Ritlecitinib

Overview
Catalog #	bs-83769c-5mg
Product Name	Ritlecitinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Ritlecitinib is potent (IC50 = 33 nM) covalent JAK3 inhibitor with exquisite selectivity over other members in its kinase class (JAK1, JAK2, TYK2).1,2 It also displays excellent kinome selectivity against 305 kinases tested. Ritlecitinib inhibits Th1 and Th17 cell differentiation and function and ameliorates symptoms in rat arthritis and mouse autoimmune encephalomyelitis models.2 It selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling. Ritlecitinib also displays activity against some TEC family kinases (BTK, BMX, ITK, RLK,TEC) leading to inhibition of the cytolytic function of CD8+ T cells and NK cells.3 Low dose Ritlecitinib significantly improved T-cell responses and decreased tumor load in louse cancer models.4 It significantly prolonged allograft survival in a mouse cardiac transplantation model.
Description	CAS Number: 1792180-81-4 Chemical Name: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one Molecular Weight: 285.35 Formula: C15H19N5O Solubility: DMSO (>100 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)