PAT-1251

Overview
Catalog #	bs-83822c-5mg
Product Name	PAT-1251
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PAT-1251 is a potent (IC50 = 710 nM) inhibitor of LOXL2, a copper-dependent amine oxidase that deaminates lysine and hydroxylysine residues in collagen and elastin. It displayed >400-fold selectivity over LOX as well as high selectivity against the related amine oxidases SSAO, DAO, and MAO-A/B. A potential new therapeutic for the treatment of fibrotic diseases.
Description	CAS Number: 2098884-53-6 Chemical Name: (R,R)-trans-(3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridine-2-yl)oxy)phenyl)(3-fluoro-4-hydroxypyrrolidin-1-yl)methanone hydrochloride Molecular Weight: 435.8 Formula: C18H17F3N3O3·HCl Solubility: DMSO (>50 mg/ml); water (>80 mg/ml) Physical Properties: White solid Purity: >98% by HPLC (NMR Conforms)