| Overview |
| bs-70108r |
| GABAA Receptor _2 Antibody |
| WB, IHC |
| Specific for endogenous levels of the ~46 kDa _2-subunit of the GABAA receptor. |
| Mouse, Rat |
| Human, Chicken, Zebrafish, Non-Human Primate |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide corresponding to amino acid residues specific to the _2 subunit of rat GABAA receptor, conjugated to keyhole limpet hemocyanin (KLH). |
| Polyclonal |
| #REF! |
| IgG |
| Lot Dependent |
| Neat Pooled whole antiserum |
| Neat whole antiserum |
| Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C. |
| Target |
| 29709 |
| P18508 |
| CAE 2 antibody, CAE2 antibody, ECA 2 antibody, ECA2 antibody, GABA(A) receptor gamma 2 antibody, GABA(A) receptor subunit gamma 2 antibody, GABA(A) receptor subunit gamma-2 antibody, GABRG 2 antibody, GABR_2 antibody, Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody, Gamma aminobutyric acid A receptor gamma 2 antibody, Gamma aminobutyric acid receptor gamma 2 subunit antibody, Gamma-aminobutyric acid receptor subunit gamma-2 antibody, GBRG2_HUMAN antibody, GEFSP 3 antibody, GEFSP3 antibody |
| Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl_ channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six _s, four _s and four _s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for _- and _-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, co-expression of a _-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different _- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pltl et al., 2003). Lastly, phosphorylation of _-subunits of the receptor has been shown to modulate GABA-A-R function (Brandon et al., 2003). |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
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