Recombinant human DUOX1 protein, N-His

Overview
Catalog #	bs-42186P-100ug
Product Name	Recombinant human DUOX1 protein, N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human DUOX1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1270-1551/1551
Storage Buffer	20mM Tris-HCl (pH8.0) with 8M Urea and 5mM DTT.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	53905
Swiss Prot	Q9NRD9
Background	Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues.