Recombinant human CD40L protein (HEK293)

Overview
Catalog #	bs-43181P-100ug
Product Name	Recombinant human CD40L protein (HEK293)
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human CD40L protein (HEK293) is expressed in HEK293 cell with N-His. It contains the amino acid sequence of 116-261/261
Storage Buffer	0.01M TBS(pH7.4)
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	959
Swiss Prot	P29965
Background	CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes.