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Recombinant SARS-COV-2 Spike RBD (N501Y, K417N, E484K) Protein

Applications

  • WB
  • ELISA
  • HPLC

Reactivity

  • SARS-CoV-2
Overview
Catalog # bs-46018P
Product Name Recombinant SARS-COV-2 Spike RBD (N501Y, K417N, E484K) Protein
Applications WB, ELISA, HPLC
Reactivity SARS-CoV-2
Specifications
Conjugation Unconjugated
Source SARS-COV-2 Spike RBD (N501Y, K417N, E484K) protein is expressed from mammalian with a His-tag at the C-terminal. 
Storage Buffer Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.
Storage Condition The product should be stored at -70°C or -20°C.
Target
Gene ID QHD43416.1
Background SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually in part due to amino acid substitutions on the SARS-CoV-2 Spike protein. The results of a study show the N501Y replacement in this region of the interface (present in both the UK and South African strains) should be favorable for the interaction with ACE2, while the K417N and E484K substitutions (South African strain) would seem neutral or even unfavorable.