ML792

Overview
Catalog #	bs-83078c-5mg
Product Name	ML792
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	ML792 is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
Description	CAS Number: 1644342-14-2 Chemical Name: [(1R,2S,4R)-4-[[5-[1-[(3-Bromophenyl)methyl]pyrazole-3-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate Molecular weight: 551.42 Formula: C21H23BrN6O5S Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)