GKT-137831

Overview
Catalog #	bs-83080c-5mg
Product Name	GKT-137831
Specifications
Storage Buffer	Pale-yellow solid
Storage Condition	-20°C
Target
Product Information	NADPH oxidase, NOX1/4 inhibitor (Ki = 100-150 nM).1 Inhibits erastin-stimulated ROS production.2 Potentiates immunotherapy by overcoming cancer-associated fibroblast- mediated CD8+ T-cell exclusion.3 Reduces ROS production in LPS-stimulated platelets in a mouse model.4 Reduces subarachnoid hemorrhage-induced neuronal death.5 Potent inhibitor of experimental liver fibrosis in mouse models.6
Description	CAS Number: 1218942-37-0 Chemical Name: 2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione Molecular weight: 394.85 Formula: C21H19ClN4O2 Solubility: DMSO (65 mg/ml) Physical Properties: Pale-yellow solid Purity: 98% by TLC NMR (Conforms)